Carboxypeptidase B2

A carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS.

Also Known As:

Thrombin Activatable Fibrinolysis Inhibitor; Carboxypeptidase R; Plasma Procarboxypeptidase B; Procarboxypeptidase U; Thrombin-Activatable Fibrinolysis Inhibitor (TAFI); Plasma Carboxypeptidase B2; Arginine Carboxypeptidase; Carboxypeptidase B2, Plasma; Carboxypeptidase U; Thrombin-Activatable Fibrinolysis Inhibitor

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloexopeptidases: 2
        Carboxypeptidase B2: 311
      - Proprotein Convertases: 494
        Carboxypeptidase B2: 311
      - Exopeptidases: 68
        Carboxypeptidases: 268
        Carboxypeptidase B2: 311
        Metalloexopeptidases: 2
        Carboxypeptidase B2: 311

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Disease

Drug/Important Bio-Agent (IBA)